Yes, and these are very important when astrologers do chart readings. For example, my sun is in the 2nd house. I grew up with very little money, and because of that I valued my career and earing money more then most other things life had to offer. Not in a greedy way, but more for stability. Like I enjoy having a large sum of money more then actual luxury, and I'll get into why that likely is later. My moon however is in the 5th house, which represents creativity, family, and children. On paper that sounds great right? Someone who makes good money, is creative, and a strong family provider sounds perfect. That's when you have to look deeper. Then you would see I have Leo sun square to Scorpio moon. This is important to note because you have 2 square fixed signs within 2 fixed houses. It's kind of a negative place to be, because the "all or nothing" nature of it ends up focusing on one thing deeply, while the other gets buried in a sense. So for me I had the option to put all my focus into a career, or all my focus into my creativity and a family. I chose the career, and find it hard to even think about balancing both. To where if I had a cancer moon or something other then a fixed sign in the 5th house, it wouldn't guarantee synergy, but the moons potential likely wouldn't have been buried as much. Then you have to look deeper into the chart. Like I mentioned, I rather have a large sum of money then actual luxury, which doesn't sound very 2nd house like. That is likely because of a strong Saturn in Capricorn.
This is just a quick example of how houses, aspects, and planet placements can act within a chart. I'll also add I'm not a professional chart reader, or even close to one. I understand the fundamentals of how charts work, but never studied them much. At the same time I get kind of offended when people call astrology bs or fake. Those type of people have no clue how deep the rabbit hole actually goes.